Rafael Bernabeu, MD, PhD

Rafael Bernabeu is a leading pioneer in the field of reproductive medicine. His curiosity and interest in reproductive medicine started at a very young age. As a teenager, he was focused on becoming a medical doctor. Upon graduating from high school, he spent six years studying medicine at the University of Valencia. Following that, he spent the next 4 years at Hospital La Fe, a university hospital in Valencia, Spain, pursuing his specialty in Obstetrics and Gynaecology. Upon completion, he began working as a gynaecologist in various clinics around the Alicante and decided to bet on a branch of gynecology that was experimental at that time. He continued with postgraduate studies in Assisted Reproduction techniques, Gynaecology and Obstetrics and attended some of the world’s leading centers like Cornell University and Johns Hopkins University. In 1985, Dr. Rafael Bernabeu created his first sperm bank and performed the first artificial insemination. This was the beginning of many firsts as a pioneer in the field of reproductive medicine.

The following are some of his achievements::

• In 1987, his first IVF was performed and in August of 1988, the first IVF baby was born.
• In 1989, Instituto Bernabeu had another success, the first pregnancy using GIFT.
• In 1990, Instituto Bernabeu implemented an embryo freezing program.
• In 1991, the first birth from a frozen embryo in Alicante, Spain.
• In 1993, the first birth from egg donation in Alicante, Spain.
• In 1994, Instituto Bernabeu reaches the mark of 100 births conceived using IVF.
• In 1995, the first baby was born through ICSI (Intra-cytoplasmic sperm injection) procedure in Alicante, Spain.
• In 1997, opening of the first building, current headquarters of Instituto Bernabeu in Alicante.
• In 1998, a baby was born using spermatids in Alicante, Spain. This is a first for Spain and the 6th worldwide.
• In 2000, Instituto Bernabeu received a Research Award from the Spanish Society of Fertility (SEF). In the same year, Instituto Bernabeu started the PGD program (genetic diagnosis for eradicating her editary diseases).
• In 2001, opening of the Instituto Bernabeu clinic in Elche, Spain.
• In 2003, opening of the Instituto Bernabeu clinic in Cartagena, Spain.
• In 2004, the first worldwide birth of a girl, free from a hereditary disease that causes blindness (retinoschisis). Pre-implantation Genetic Diagnosis techniques developed at Instituto Bernabeu (MDA) were used. The same year, the first Department Chair of Reproductive Medicine in Europe was established in collaboration with Miguel Hernández University.
• In 2006, the first child was born free from Marfan syndrome. The technique of Pre-implantation Genetic Diagnosis developed at Instituto Bernabeu was used. This same year, Instituto Bernabeu was accredited with ISO 9001 and SEP (Private Healthcare Excellence) in all patient care processes, the first center of reproductive medicine and gynecology in Valencia and Murcia Regions to achieve these certifications.
• In 2007, the Rafael Bernabeu Foundation was born. Dr. Rafael Bernabeu was nominated for the James I Award in the medical research category.
• In 2008, Opening of Instituto Bernabeu clinic in Benidorm, Spain. In the same year, Instituto Bernabeu was honoured twice. Firstly, the Confederation of Physically Handicapped in the Valencia Region (COCEMFE) honors both Instituto Bernabeu and the Rafael Bernabeu Foundation, for its "excellent scientific research work". Secondly, Instituto Bernabeu was accredited with a "Committed to Excellence" award by the European Foundation for Quality Management (EFQM).
• In 2009, Instituto Bernabeu Biotech is born as a Biotechnology, Molecular Biology and Genetics branch of Instituto Bernabeu. In their first year, Biotech received the ASEBIR 2009 Award for Basic Research.
• In 2010, Instituto Bernabeu Biotech received its first patent. It won the national Award for Basic Research from the Spanish Fertility Society (SEF) and the "Niccolo Paganini" Award at the International Congress for Marfan syndrome for their advances in the fight to eradicate the disease.
• In 2011, Instituto Bernabeu won more awards. First, the ICIRA Award for relevant data inputs in assisted reproduction treatments; the second, a National Award from SEGO in the ultrasound section for the best work in "ultrasound in gynecology"; and finally, the San Alberto Magno Award from the University of Alicante for "quality of teaching". That year, Instituto Bernabeu created an altruistic programme for the preservation of fertility in patients suffering from breast cancer.
• In 2012, Instituto Bernabeu is awarded 2nd prize by the American Society for Reproductive Medicine (ASRM) in the best poster category.
• In 2013, the Department Chair of Reproductive Medicine at the University of Alicante was created. This was also the year for the 25th Anniversary of the first IVF birth of a child in the Valencia Region.
• In 2013, Dr. Bernabeu is appointed Referee of national and international publications on fertility for 'Reproductive BioMedicine Online (RBMOnline)'.
• In 2014, he is granted the Recognition for Lifetime Achievement Award in the category of "Other Healthcare fields" by the General Council of Medical Associations.
• In 2015, Dr. Bernabeu is awarded the first place prize for original work. 8th Edition of Angel Bayo Awards. ASESA (Spanish Andrology Society). Title of the award-winning project: "Study of structural damage after sperm immobilisation prior to intracytoplasmic sperm injection in teratozoospermic males".
• In 2015, opening of Instituto Bernabeu clinic in Albacete, Spain.
• In 2015, Instituto Bernabeu and the University of Castilla La Mancha sign a collaboration agreement to promote R&D in the field of Reproductive Medicine.
• In 2015, First prize from the Spanish Association of Andrology (ASESA) for the best original research work.
• In 2015, Instituto Bernabeu is awarded the QH recognition of Excellence in Quality Healthcare.
• In 2015, Instituto Bernabeu is the first clinic in the Valencia and La Mancha regions of Spain to be awarded the new UNE 179007 quality certification in assisted reproduction.
• En 2015, Dr Bernabeu is appointed Referee of national and international publications on fertility for “Fertility & Sterility".
• In 2016, Dr Rafael Bernabeu IS appointed Vice-President of the Sterility and Infertility Section of the SEGO (Spanish Society of Obstetrics and Gynaecology).
• In 2016, Instituto Bernabeu Poor Ovarian Response Unit along with IB Biotech –our genetics team-, discover the genes involved in ovarian reserve. IBgen IVF.
• In 2016, The Ministry recognized Instituto Bernabeu as an innovative company for its R&D work.
• In 2016, Instituto Bernabeu is awarded the IN4Bankia Prize for Innovation.
• In 2017, Opening of Instituto Bernabeu clinic in Madrid, Spain.
• In 2017, Dr. Bernabeu is appointed Referee of national and international publications on fertility for 'Human Reproduction'.
• In 2018, Instituto Bernabeu identifies the genetic variants involved in implantation failure and repeat miscarriages.
• In 2019, opens Instituto Bernabeu clinic in Palma de Mallorca, Spain.
• In 2020, is appointed Academic of the Royal Academy of Medicine of Zaragoza.
• En 2021, Instituto Bernabeu in Venice was inaugurated; the first international IB branch.

Dr. Rafael Bernabeu has represented reproductive medicine interests on several national and international committees. He participated on the executive committee of the Spanish Fertility Society. He was the Founder and First President of ANACER (National Association of Centres of Reproductive Medicine). His clinical research interests include current treatment options in repeat implantation failure, recurring pregnancy losses and severe male factors.

He/She has published more than 120 articles in prestigious national and international journals of Reproductive Medicine: Human Reproduction, Fertility and Sterility, Reproductive Biomedicine Online, Journal of Assisted Reproduction and Genetics, Histology and Histopathology, Ebioforum Europe, among others, as well as chapters in different specialised books, and has participated in more than 400 research studies presented at national and international congresses.

Dr. Rafael Bernabeu has been an ultra-deep runner and currently maintains adequate physical activity. He enjoys reading multiple disciplines and listening to different types of music.

Visit abbreviated curriculum of Rafael Bernabeu, MD, PhD
Visit INSTITUTO BERNABEU web page.
Visit INSTITUTO BERNABEU Medical Team.

International Scientific Publications

• Implicit bias in diagnosing mosaicism amongstpreimplantation genetic testing providers
  Date: 27 November 2023

  Human Reproduction, september 2023 M. Popovic, L. Borot, A. R. Lorenzon, A. L. Rossi de Castro Lopes, D. S, B. Lledó, R. Morales, J. A. Ortiz, N. P. Polyzos, M. Parriego, F. Azpiroz, M. Galain, A. Pujo, B. Menten, L. Dhaenens, F. V. Meerschaut, D. Stoop, M. Rodriguez, E. Pérez de la Blanca, A Rodríguez, and R. Vassena

• Random-start ovarian stimulation in an oocyte donation programme: a large, single-centre, experience
  Date: 27 November 2023

  Reproductive BioMedicine Online, octover 2023 J. Guerrero, J.C. Castillo, J. Ten, F. Quereda, A. Bernabeu, R. Bernabeu

• Time-sensitive assessment of luteal phaseprogesterone after HCG ovulation triggering:another brick off the wall?
  Date: 21 November 2023

  Reproductive BioMedicine Online, july 2023 J.C. Castillo, S. Kol

• Factors associated with embryo mosaicism: a systematic reviewand meta‑analysis
  Date: 14 September 2023

  Journal of Assisted Reproduction and Genetics, august 2023 A. Cascales, R. Morales, A. Castro, J.A. Ortiz, B. Lledo, J. Ten, A. Bernabeu, R. Bernabeu

  Ver vídeo
• Identification of novel candidate genes associated with meioticaneuploidy in human embryos by whole‑exome sequencing
  Date: 09 June 2023

  Journal of Assisted Reproduction and Genetics may 2023 B. Lledo, A. Marco, R. Morales, J.A. Ortiz, E. García-Hernández, F.M. Lozano, A. Cascales, J. Guerrero, A. Bernabeu, R. Bernabeu

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• Noninvasive preimplantation genetic testing using the embryo spent culture medium: an update
  Date: 09 June 2023

  Current Opinion in Obstetrics and Gynecology, May 2023 B. Lledó, R. Morales, J.A. Ortiz, A. Bernabeu, R. Bernabeu

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• Characterization of the Endometrial Microbiome in Patients with Recurrent Implantation Failure
  Date: 18 April 2023

  Microorganism, March 2023 F. M. Lozano, B. Lledó, R. Morales, A. Cascales, M. Hortal, A. Bernabeu, R. Bernabeu

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• Exploring self-detection of the endogenous LH surge using a urine test as a tool to predict a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles
  Date: 03 April 2023

  JBRA Assisted Reproduction, February 2023 M. Martinez, R. Delgado, E. Quevedo, J. Guerrero, H. Moragues, J. A. Ortiz, A. Bernabeu, J. C. Castillo, R. Bernabeu

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• Oocyte donors and mRNA Covid-19 vaccination: Is there any impact on ovarian stimulation parameters or in IVF outcomes for recipients?
  Date: 26 January 2023

  Reproductive BioMedicine Online, January 2023 A.Bosch; S. Albero; J. Castillo; J. Ten; J. Guerrero; J.A. Ortiz; A. Bernabeu; R. Bernabeu

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• Vitrification does not affect birth weight: lessons from the oocyte donation model
  Date: 19 December 2022

  Reproductive BioMedicine Online, August 2022 J. Llácer, N. Díaz, E. Serrano-Revuelta, E. Álvarez, JC. Castillo, JA. Ortiz, J. Ten, A. Bernabeu, R. Bernabeu

• IL-6/IL-10 and IL-1β/IL-4 ratios associated with poor ovarian response in women undergoing in-vitro fertilization
  Date: 22 November 2022

  European Journal of Obstetrics & Gynecology and Reproductive Biology, November 2022 M. Hortal, A. Fabregat, B. Lledo, J. A. Ortiz, B. Moliner, A. Bernabeu, R. Bernabeu

• Application of machine learning to predict aneuploidy and mosaicism in embryos from in vitro fertilization cycles
  Date: 22 November 2022

  American Journal of Obstetrics Gynecology, November 2022 J. A .Ortiz, R. Morales, B. Lledó, J. A. Vicente, J. González, E. M. García-Hernández, A. Cascales, J. Ten, Andrea Bernabeu, R. Bernabeu

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• Identification of new variants and candidate genes in women with familial premature ovarian insuficiency using whole exome sequencing
  Date: 22 November 2022

  Journal of Assisted Reproduction and Genetics, Octover 2022 R. Morales, B. Lledo, J. A. Ortiz, F. M. Lozano, E. M. García, A. Bernabeu, A. Fuentes, R. Bernabeu

• FSH receptor genotype and its influence on the results of donor ovarian stimulation using corifollitropin alfa
  Date: 28 September 2022

  Reproductive BioMedicine Online, July 2022 B. Lledó, J.A. Ortiz, M. Hortal, A. Cascales, R. Morales, J. Guerrero, A. Bernabeu, R. Bernabeu

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• Identification of vaginal microbiome associated with IVF pregnancy
  Date: 02 May 2022

  Scientific Reports, April 2022 B. Lledo, A. Fuentes, F. M. Lozano, A. Cascales, R. Morales, M. Hortal, F. Sellers, A. Palacios‑Marques, R. Bermejo, F. Quereda, J. C. Martínez‑Escoriza,
  R. Bernabeu, A. Bernabeu

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• Methylenetetrahydrofolate reductase gene polymorphisms are not associated with embryo chromosomal abnormalities and IVF outcomes
  Date: 09 September 2021

  Systems Biology in Reproductive Medicine, May 2021 R. Morales, B. Lledó, JA. Ortiz, A. Cascales, H. Codina, A. Rodríguez-Arnedo, J.LL. Aparicio, A. Bernabeu, R. Bernabeu

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• Impact of the Vaginal and Endometrial Microbiome Pattern on Assisted Reproduction Outcomes
  Date: 09 September 2021

  Clinical Medicine , September 2021 María del Carmen Diaz‐Martínez, Andrea Bernabeu, Belén Lledó, Concepción Carratalá‐Munuera, Jose A. Quesada, Francisca M. Lozano, Vicente Ruiz, Ruth Morales, J. Ll. Aparicio, Jorge Ten, Juan Carlos Castillo, Adoración Rodríguez, Rauf Nouni‐García, Adriana López‐Pineda, Belén Moliner and Rafael Bernabeu

• The Effect of Twisted Uterus Caused by Endometriosis or Myomatosis on Reproductive Treatment Outcomes
  Date: 12 August 2021

  Journal of Family and Reproductive Health, June 2021 Belen Moliner; M.D. Ph.D., Francisco Sellers; M.D. Ph.D., Andrea Bernabeu; M.D. Ph.D., Ana Fuentes; M.D., Juan Carlos Castillo; M.D. Ph.D., J. Ll. Aparicio; M.D. Ph.D., Rafael Bernabeu; M.D.

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• Characterization of the vaginal and endometrial microbiome in patients with chronic endometritis
  Date: 17 June 2021

  European Journal of Obstetrics & Gynecology and Reproductive Biology, 30 May 2021 F.M. Lozano, A. Bernabeu, B. Lledo, R. Morales, M. Diaz, F.I. Aranda, J. Ll. Aparicio, R. Bernabeu

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• 4D ultrasound as a method to assess uterine peristalsis
  Date: 20 March 2021

  Fertility & Sterility, 30 March 2021 B. Moliner, J. Ll. Aparicio, F. Sellers, J. C. Castillo, A. Fuentes, A. Bernabeu, R. Bernabeu

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• The Association between Vaginal Dysbiosis and Reproductive Outcomes in Sub-Fertile Women Undergoing IVF-Treatment: A Systematic PRISMA Review and Meta-Analysis
  Date: 17 March 2021
  Pathogens, 4 March 2021. Axel Skafte-Holm, Peter Humaidan, Andrea Bernabeu, Belén Lledó, Jorgen Skov Jensen and Thor Haahr.
• Exploring the epigenetic profile of women with poor ovarian reserve
  Date: 02 March 2021

  Fertility and Sterility, March ’21. Rafael Bernabeu, José A. Ortíz, Belén Lledó.

• Sperm DNA fragmentation on the day of fertilisation is not associated with assisted reproductive technique outcome independently of gamete quality
  Date: 28 January 2021

  Human Fertility, 27 Jan 2021. Jorge Ten, Jaime Guerrero, Ángel Linares, Adoración Rodríguez-Arnedo, Ruth Morales, Belén Lledó, Ll. Aparicio & Rafael Bernabeu.

• Effect of ovarian stimulation on embryo aneuploidy and mosaicism rate
  Date: 07 January 2021

  Systems Biology in Reproductive Medicine, Jan 2021. Alba Cascales , Belen Lledó , Jose A. Ortiz , Ruth Morales , Jorge Ten , Joaquin Ll. Aparicio & Rafael Bernabeu

• Consistent results of non-invasive pre-implantation genetic testing for aneuploidy (niPGT-A) of human embryos using two different techniques for chromosomal analysis
  Date: 20 December 2020

  Reproductive BioMedicine Online, December 2020.  B. Lledo, R. Morales, J.A. Ortiz, A. Rodriguez-Arnedo, J. Ten, J.C. Castillo, A. Bernabeu, J. Ll. Aparicio, R.Bernabeu. 

• Expert consensus for primary management of reproductive health: a Delphi study
  Date: 28 September 2020

  Expert consensus for primary management of reproductive health: a Delphi study. September 2020. Andrea Bernabeu, Concepcion Carratala-Munuera, Jose A. Quesada, Ll. Aparicio, Adriana Lopez-Pineda, Francisco Sellers, Vicente F. Gil-Guillen, Rafael Bernabeu, Kamila Cheikh-Moussa, Domingo Orozco-Beltran

• Monozygotic twinning following embryo biopsy at the blastocyst stage
  Date: 20 September 2020

  JBRA Assisted Reproduction Journal of Medical Sciences: September 2020. Rafael Sellers, Juan Carlos Castillo, Jorge Ten, Adoración Rodríguez, José A. Ortiz, Francisco Sellers, Ll. Aparicio, Rafael Bernabeu

• Gonadotropin-releasing hormone agonist ovulation trigger—beyond OHSS prevention
  Date: 25 March 2020

  Upsala Journal of Medical Sciences. Juan Carlos Castillo, Thor Haahr, María Martínez-Moya & Peter Humaidan

• Sonographic Assessment of Uterine Fibroids and Adenomyosis
  Date: 29 February 2020

  Gynaecological Ultrasound Scanning. Francisco Sellers López, Belén Moliner Renau and Rafael Bernabeu Pérez

• Luteal phase stimulation versus follicular phase stimulation in poor ovarian responders: results of a randomized controlled trial
  Date: 07 February 2020

  Reproductive Biology and Endocrinology. Ll. Aparicio, Belén Moliner, Lydia Luque, Andrea Bernabeu, Belén Lledó, Juan Carlos Castillo, Jaime Guerrero, Jorge Ten, Rafael Bernabéu.

• Ovarian hyperstimulation syndrome following GnRH agonist trigger for final follicular maturation in a patient undergoing random start ovarian stimulation for egg-donation cycle with an inadvertent concomitant early pregnancy
  Date: 26 December 2019

  Gynecological Endocrinology: December 2019. Juan Castillo, Ll. Aparicio, Ricardo Delgado, Jaime Guerrero, Rafael Bernabeu.

• Comparison of the assisted reproductive technology outcomes between conventional IVF and ICSI with donor oocytes in normozoospermic patients
  Date: 08 November 2019

  Human Fertility: November 2019. Jorge Ten, Patricia Peinado, Jaime Guerrero, Andrea Bernabeu, Joaquín Ll. Aparicio, Domingo Orozco-Beltran, Concepcion Carratala-Munuera, Rafael Bernabeu.

• The relevance of the individual screening for genetic variants in predicting ovarian response
  Date: 01 November 2019

  Pharmacogenetics and Genomics: November 2019 – Volume 29 – Issue 9 – p 216–223. Belén Lledó; Ll. Aparicio; Laura Blanco; José A. Ortiz; Ruth Morales; Ana Fabregat; Jaime Guerrero; Rafael Bernabeu.

• Effect of the vaginal microbiome on the pregnancy rate in women receiving assisted reproductive treatment
  Date: 24 August 2019

  Journal of Assisted Reproduction and Genetics. August 2019. Andrea Bernabeu, Belén Lledo, Ma. Carmen Díaz, Francisca M. Lozano, Vicente Ruiz, Ana Fuentes, Adriana Lopez-Pineda, Belen Moliner, Juan Carlos Castillo, Jose Antonio Ortiz, Jorge Ten, Ll. Aparicio, Concepcion Carratala-Munuera, Domingo Orozco-Beltran, Jose A. Quesada, Rafael Bernabeu.

• The use of fluorescence in situ hybridization analysis on sperm: indications to perform and assisted reproduction technology outcomes
  Date: 08 August 2019

  Journal of Assisted Reproduction and Genetics. August 2019. Zaida Sarrate, Joan Blanco, Fernando Marina-Rugero, Juan Manuel Moreno-García, Miguel Ruiz-Jorro, Rafael Lafuente-Varea, Fernando Graña-Zanón, Rocío Núñez-Calonge, Jorge Ten, Joaquín Rueda.

• Comparison of two closed carriers for vitrification of human blastocysts in a donor program
  Date: 16 December 2018

  Cryobiology, December 2018, Jaime Guerrero, Miguel Gallardo, Adoración Rodríguez-Arnedo, Jorge Ten, Rafael Bernabeu

• Comprehensive mitochondrial DNA analysis and IVF outcome
  Date: 15 November 2018

  Human Reproduction Open, pp. 1–9, 2018. November 2018. B. Lledo, J.A. Ortiz, R. Morales, E. García-Hernández, J. Ten, A. Bernabeu, J. Ll. Aparicio, R. Bernabeu.

• Clinical outcomes in elective vitrification of embryos
  Date: 01 November 2018

  Revista Oficial de la Sociedad Española de Ginecología y Obstetricia, Prog Obstet Ginecol 2018;61(5):438-443. November 2018. Rafael Sellers Gil, Jorge Ten Morro, Mª Carmen Tió Marquina, Francisco Sellers López, and Rafael Bernabeu Pérez.

• Prevalence of candidate single nucleotide polymorphisms on p53, IL-11, IL-10, VEGF and APOE in patients with repeated implantation failure (RIF) and pregnancy loss (RPL)
  Date: 15 October 2018

  Human Fertility. October 2018. Azahara Turienzo, Belén Lledó, José A. Ortiz, Ruth Morales, Juan Sanz, Ll. Aparicio & Rafael Bernabeu.

• A pharmacogenetic approach to improve low ovarian response: The role of CAG repeats length in the androgen receptor gene
  Date: 01 August 2018

  European Journal of Obstetrics & Gynecology and Reproductive Biology. Volume 227, August 2018, Pages 41-45. B.Lledó, J.Ll. Aparicio, JA.Ortiz, B.Martinez, R.Morales, R.Bernabeu.

• Does embryo mosaicism affect clinic results in assisted reproduction cycles?
  Date: 03 October 2017

  Young Investigator Award winner.

  Abstracts for 2017 Foundation for Reproductive Medicine Translational Reproductive Biology and Clinical Reproductive Endocrinology Conference. 

  J Assist Reprod Genet (2017) 34:1385–1402. October 2017. Andrea Bernabeu, José Antonio Ortiz, Belén Lledó, Ruth Morales, Elena Fernández, Jorge Ten, Rafael Bernabeu.

• Estudio del volumen y la vascularización trofoblástica mediante power doppler tridimensional en la novena semana en gestaciones espontáneas y tras técnicas de reproducción asistida
  Date: 11 June 2017

  Elsevier. 154-161. Junio 2017. Francisco Sellers, Belén Moliner, Ana Palacios, Rafael Sellers, Ll. Aparicio y Rafael Bernabeu.

• Human sperm motility, capacitation and acrosome reaction are impaired by 2- arachidonoylglycerol endocannabinoid.
  Date: 01 June 2017

  Histology and Histopathology. 11-911. June 2016. M.M. Francou, J.L. Girela, A. De Juan, J. Ten, R. Bernabeu, J. De Juan. 

• Implantation potential of mosaic embryos.
  Date: 17 March 2017

  Systems Biology in Reproductive Medicine. Vol63, NO.3, 206-208. April 2017. B. Lledó, R. Morales, JA. Ortiz, H. Blanca, J. Ten, J. Ll. Aparicio, R. Bernabeu. 

• Congenital anomalies after assisted reproduction techniques and their correlation with embryonic quality
  Date: 15 November 2016

  Revista Iberoamericana de Fertilidad. Vol. 33 nº 4. November 2016. Francisco Sellers López, Belén Moliner Renau, Jorge Ten Morro, Jaime Guerrero Villena, Ana Palacios Marqués, Rafael Bernabeu Pérez.

• Study of placental vascularization using 3D Power Doppler on week 20 of spontaneous pregnancies and after assisted reproductive techniques
  Date: 15 October 2016

  Revista Iberoamericana de Fertilidad. Vol. 33 nº 4. October 2016. Francisco Sellers López, Belén Moliner Renau, Ana Palacios Marqués, Rafael Bernabeu Pérez.

• Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos
  Date: 25 August 2016

  Systems Biology in Reproductive Medicine. Vol. 62,  Issue 5, pp 317-324. August 2016. Ruth Morales, Belén Lledó, José A. Ortiz, Jorge Ten, Joaquin Ll. Aparicio & Rafael Bernabeu.

• Clinical efficacy of recombinant versus highly purified follicle-stimulating hormone according to follicle-stimulating hormone receptor genotype
  Date: 17 May 2016

  Pharmacogenetics Genomics. Vol 26 (6), 288-93. June 2016.  Belén Lledó, Patricia Dapena, Jose A. Ortiz, Ruth Morales, Joaquín Ll. Aparicio and Rafael Bernabeu

• Can reproductive medicine help to understand the aetiopathogenesis of pre-eclampsia?
  Date: 01 April 2016

  Reproductive Medicine and Clinical Embryology (MEDRE). Vol. 03, 1-3. 2016. F. Sellers, J. Ll. Aparicio y R. Bernabeu. 

• Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization
  Date: 01 November 2015

  Reproductive Biology and Endocrinology. November 2015. M.J. Gómez, E.M. García, J. Guerrero, S. Medina, M. J. Izquierdo, A. Gil, J. Orduna, M. Saviron, J. Ten, R. Bernabeu, M. Avilés, L. González. 

• Efecto de la Vitrificación de Ovocitos Humanos sobre la Capacidad de Unión y el Estado Acrosomal de Espermatozoides Humanos
  Date: 01 June 2015

  International Journal of Morphology. June 2015, Ismael Vilella; Eva Mª García.; Jorge Ten; Rafael Bernabeu; Yolanda Segovia Huerta; María José Gómez-Torres

• Androgen receptor CAG repeat length is associated with ovarian reserve but not with ovarian response.
  Date: 01 October 2014

  RBMOnline. Vol. 29, 509-515. October 2014. B. Lledo, J. Ll. Aparicio, A. Turienzo, J.A. Ortiz, J. Guerrero, R. Morales, J. Ten, R. Bernabeu.

• Pharmaceutical options for triggering of final oocyte maturation in ART.
  Date: 01 July 2014

  BioMed Research International. vol. 2014, Article ID 580171, 7 pages, 2014. doi:10.1155/2014/580171. July 2014. J. C. Castillo, P. Humaidan, and R. Bernabeu

• Pharmacogenetics of ovarian response
  Date: 02 June 2014

   Pharmacogenomics. 15 (6), pp 885-893. June 2014. B. Lledó, J. A. Ortíz, J. Ll. Aparicio, R. Bernabeu

• A multicenter prospective study to assess the effect of early cleavage on embryo quality, implantation, andlive-birth rate
  Date: 01 April 2014

  Fertility and Sterility Vol. 104, Issue 4. Pages 981-987. April 2014. Maria José de los Santos, Ph.D.,Gemma Arroyo, Ph.D.,Ana Busquet, Ph.D.,Gloria Calderon, Ph.D.,Jorge Cuadros, Ph.D.,Maria Victoria Hurtado de Mendoza, Ph.D.,Marta Moragas, Ph.D.,Raquel Herrer, Ph.D., Agueda Ortiz, Ph.D.,Carme Pons, M.Sc.,Jorge Ten, Ph.D.,Miguel Angel Vilches, Ph.D., and Maria Jose Figueroa, Ph.D., for the ASEBIR Interest Group in Embryology.

• Study of structural damage after sperm immobilisation prior to intracytoplasmic sperm injection in teratozoospermic males.
  Date: 14 January 2014

  International Journal of Andrology. Volume 12 (1):10–15. January-March 2014. María José Gómez-Torresa, Eva María García, Jaime Guerrero, Jose Luis Girela, Jorge Tena, Rafael Bernabeub y Joaquín De Juan. 

  First place prize for original work. 8th Edition of Angel Bayo Awards. ASESA (Spanish Andrology Society). June 2015.

• Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss
  Date: 01 November 2013

  Journal of Assisted Reproduction and Genetics. November 2013.B. Lledó, A. Turienzo, J.A. Ortíz, R. Morales, J. Ten, J. Ll. Aparicio, and R. Bernabeu.

• Capacitation and acrosome reaction changes α-tubulin immunodistribution in human spermatozoa
  Date: 01 October 2013

  RBMOnline. October 2013. M.M. Francou, J. Ten, J. De Juan and R. Bernabeu.

• Characterization of a balanced complex chromosomal rearrangement carrier ascertained through a fetus with dup15q26.3 and del5p15.33: case report
  Date: 01 August 2013

  Human Fertility. August 2013. B. Lledó, J. A. Ortiz, R. Morales, I. Manchón, F. Galán, A. Bernabeu and R. Bernabeu.

• Effect of follicle-stimulating hormone receptor N680S polymorphism on the efficacy of follicle-stimulating hormone stimulation on donor ovarian response.
  Date: 01 March 2013

   Pharmacogenetics and Genomics. March 2013. B. Lledo, J. Guerrero, A. Turienzo, J.A. Ortiz, R. Morales, J. Ten, J. Ll. Aparicio and R. Bernabeu.

• Uterine arteriovenous malformation
  Date: 01 February 2013

  British Medical Journal (BMJ) Case Rep 2013.doi: 10.1136/bcr-2012-008443. February 2013.F. Sellers, A. Palacios, B. Moliner, R. Bernabeu.

• New Approach for Chemometric Analysis of Mass Spectrometry Data
  Date: 01 February 2013

  Analytical Chemistry. Vol.85 (6).pp 3053-3058. February 2013. F.C. Marhuenda-Egea, R. D. Gonsálvez-Álvarez, B. Lledó-Bosch, J. Ten, R. Bernabeu.

• Androgen receptor Polymorphisms are associated with poor ovarian response
  Date: 03 September 2012

  Fertility and Sterility Vol. 98, Issue 3, Supplement, Page S114. September 2012. ASRM Abstracts. J. Ll. Aparicio, J.A. Ortiz, J. Guerrero, B. Lledó, J. Ten, R. Bernabeu.2nd place ASRM award for the best conference poster.

• Sperm deoxyribonucleic acid fragmentation level, as measured by tunel test, is not related with the IVF outcome in good prognosis women.
  Date: 03 September 2012

  Fertility and Sterility Vol. 98, Issue 3, Supplement, Page S150. September 2012. ASRM Abstracts. B. Lledó, R. Morales, A. Rodríguez, J. Ten, R. Bernabeu.

• High ovarian stimulation doesn’t impair embryo quality. Clinical evidence using comparative model with shared egg donors
  Date: 03 September 2012

  Fertility and Sterility Vol. 98, Issue 3, Supplement, Pages S171-S172. September 2012. ASRM Abstracts. J. Ll. Aparicio, B. Moliner, A. Rodríguez, J. Guerrero, J. Ten, R. Bernabeu.

• Effect of polymorphism in the promoter estrogen receptor alpha on sperm count
  Date: 03 September 2012

  Fertility and Sterility Vol. 98, Issue 3, Supplement, Page S243. September 2012.ASRM Abstracts. B. Lledó, A. M. Fabregat, R. Morales, J. A. Ortiz, J. Ll. Aparicio, R. Bernabeu.

• Intermediate and normal sized CGG repeat on the FMR1 gene does not negatively affect donor ovarian response
  Date: 01 February 2012

  Human Reproduction Vol. 27, No. 2. pp 609-614. February 2012. B. Lledo, J. Guerrero, J.A. Ortiz, R. Morales, J. Ten, J. Ll. Aparicio, J. Giménez, R. Bernabeu.

• Correlations between Different Heavy Metals in Diverse Body Fluids: Studies of Human Semen Quality
  Date: 02 January 2012

  Advances in Urology. Vol. 2012, Art. ID 420893, 11 pages. 2012. L. Mínguez-Alarcón, J. Mendiola, M. Roca, J.J. López-Espín, J.J. Guillén, J.M. Moreno, S. Moreno-Grau, M.J. Martínez-García, N. Vergara-Juárez, B. Elvira-Rendueles, A. García-Sánchez, J. Ten, R. Bernabeu, A.M. Torres-Cantero.

• Relationships between heavy metal concentrations in three different bodily fluids and male reproductive parameters: a pilot study
  Date: 03 January 2011

  Environmental Health. 10:6. 2011. J. Mendiola, J.M. Moreno, M. Roca, N. Vergara-Juárez, M.J. Martínez-García, A. García-Sánchez, B. Elvira-Rendueles, S. Moreno-Grau, J.J. López-Espín, J. Ten, A.M. Torres-Cantero, R. Bernabeu.

• Improving human embryos selection in IVF: non-invasive metabolomic and chemometric approach
  Date: 03 January 2011

  Metabolomics (2011) 7:247-256. 2011. F. C. Marhuenda-Egea, R. Gonsálvez-Álvarez, E. Martínez-Sabater, B. Lledó, J. Ten, R. Bernabeu.

• Analysis of Placental Vascularization by Means of 3D Power Doppler in Women Pregnant Following Oocyte Donation
  Date: 02 August 2010

  Reproductive Sciences. Vol. 17, No. 8, pp 754-759. August 2010. F. Sellers López, D. Orozco-Beltrán, V. Gil-Guillen, J.M. Lozano, A. Palacios, R. Bernabeu.

• The paternal effect of chromosome translocation carriers observed from meiotic segregation in embryos
  Date: 01 July 2010

  Human Reproduction. Vol. 25, No. 7, pp 1843-1848. July 2010. B. Lledó, J.A. Ortiz, R. Morales, J. Ten, P.E. de la Fuente, C. García-Ochoa, R. Bernabeu

• A crucial step in assisted reproduction technology: human embryo selection using metabolomic evaluation
  Date: 01 July 2010

  Fertility and Sterility. Vol. 94. No. 2. 772-774, July 2010.F.C. Marhuenda-Egea, E. Martínez-Sabater, R. Gonsálvez-Álvarez, B. Lledó, J. Ten, R. Bernabeu.

• A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics
  Date: 01 March 2010

  Fertility and Sterility. Vol. 93, No. 4, March 1, 2010. J. Mendiola, A. M. Torres-Cantero, J. Vioque, J. M. Moreno-Grau, J. Ten, M. Roca, S. Moreno-Grau, R. Bernabeu.

• Food intake and its relationship with semen quality: a case-control study
  Date: 02 March 2009

  Fertility and sterility Vol. 91, Nº3, March 2009. J. Mendiola, A.M. Torres-Cantero, J.M. Moreno-Grau, J. Ten, M. Roca, S. Moreno Grau, R. Bernabeu.

• Exposure to environmental toxins in males seeking infertility treatment: a case-controlled study
  Date: 01 January 2008

  Reproductive BioMedicine Online. Vol. 16, No 6, 842-850. 2008.J. Mendiola, A.M. Torres-Cantero, J.M. Moreno-Grau, J. Ten, M. Roca, S. Moreno-Grau, R. Bernabeu.

• Occupational and Lifestyle Exposures on Male Infertility: A Mini Review
  Date: 01 January 2008

  The Open Reproductive Science Journal. Vol. 1, 16-21. 2008. J. Ten, J. Mendiola, A.M. Torres-Cantero, J.M. Moreno-Grau, S. Moreno-Grau, M. Roca, J. Romero and R. Bernabeu.

• Preimplantation genetic diagnosis of X-linked retinoschisis
  Date: 01 January 2008

  Reproductive BioMedicine Online Vol. 16, No. 6, 886-892. 2008. B. Lledó, J. Ten, D. Rodríguez-, J. Ll. Aparicio, R. Bernabeu.

• Preimplantation genetic diagnosis of X-linked adrenoleukodystrophy with gender determination using multiple displacement amplification
  Date: 01 November 2007

  Fertility and Sterility. Vol. 88, No. 5, 1327-1333. November 2007. B. Lledo, R. Bernabeu, J. Ten, F.M. Galan, L. Cioffi.

• Sperm immobilized before intracytoplasmic sperm injection undergo ultrastructural damage and acrosomal disruption
  Date: 03 September 2007

  Fertility and Sterility. Vol. 88, No.3, 702-704. September 2007. M.J. Gomez-Torres, J. Ten, J.L. Girela, J. Romero, R. Bernabeu, J. De Juan.

• Sperm immobilized before intracytoplasmic sperm injection undergo ultrastructural damage and acrosomal disruption
  Date: 01 September 2007

  Fertil Steril, 2007. Maria Jose Gómez-Torres, Ph.D., Jorge Ten, Ph.D., Jose L. Girela, Ph.D., Jesús Romero, M.D., Ph.D., Rafael Bernabeu, M.D., and Joaquín De Juan, M.D., Ph.D.

• Quantifying sHLA-G in IVF Culture Media as a Marker of Embryonic Viability and Implantation Potential
  Date: 01 September 2007

  American Journal of Reproductive Immunology Vol. 58, No. 3, pages: 206-207. Sept. 2007 S. Martí, J. Ten, P. Marcos, M.J. Artacho, F.J. Galán, R. Bernabeu, G. Rubio

• Development of Assisted Reproduction. Past, Present and Future of Technologies
  Date: 01 January 2007

  Bioforum Europe. Vol. 11, 64-65. 2007. B. Lledó, J. Ll. Aparicio, J. Ten and R. Bernabeu.

• Donor oocyte dysmorphisms and their influence on fertilization and embryo quality
  Date: 01 January 2007

  Reproductive BioMedicine Online. Vol. 14. No. 1, 40-48. January 2007.J. Ten, J. Mendiola, J. Vioque, J. de Juan, R. Bernabeu.

• Preimplantation genetic diagnosis of Marfan syndrome using multiple displacement amplification
  Date: 02 October 2006

  Fertility and Sterility. Vol. 86, No. 4, 949-955. October 2006. B. Lledó, J. Ten, F.M. Galán, R. Bernabeu.

• Indomethacin effect on implantation rates in oocyte recipients
  Date: 01 February 2006

  Human Reproduction. Vol. 21, No. 2. pp. 364-369. February 2006. M. Roca, A. Torres, J. Ten, R. Bernabeu.

• Analysis of factors influencing pregnancy rates in homologous intrauterine insemination
  Date: 03 May 2004

  Fertility and Sterility Vol. 81, No. 5, 1308-1313. May 2004. G. Ibérico, J. Vioque, N. Ariza, J.M. Lozano, M. Roca, J. Ll. Aparicio, R. Bernabeu.

• Follicular fluid markers of oocyte developmental potential
  Date: 01 April 2002

  Human Reproduction. Vol. 17, No.4. pp 1017-1022. April 2002. C. Mendoza, E. Ruiz-Requena, E. Ortega, N. Cremades, F. Martínez, E. Greco, J. Tesarik and R. Bernabeu.

• Historical comment on the debate: embryo implantation is the rubicon for the GnRH antagonist, and answer
  Date: 01 October 2001

  Human Reproduction. Vol. 16, No. 10, p. 2247. October 2001. R. Bernabeu.

• Developmental potential of elongating and elongated spermatids obtained after in-vitro maturation of isolated round spermatids
  Date: 03 September 2001

  Human Reproduction. Vol. 16, No.9. pp. 1938-1944, September 2001. N. Cremades, M. Sousa, A. Barros and R. Bernabeu.

• In-vitro maturation of round spermatids using co-culture on Vero cells
  Date: 03 May 1999

  Human Reproduction. Vol. 14, No. 5. pp. 1287-1293. May 1999.N. Cremades, A. Barros, M. Sousa, R. Bernabeu.

• Effects of Agonist dose on in-vitro fertilization
  Date: 01 October 1998

  Human Reproduction. Vol.13. No. 10. pp. 2973-2974. October 1998. C. Álvarez and R. Bernabeu.

• Successful pregnancy after spermatid injection
  Date: 01 July 1998

  Human Reproduction Vol. 13, No.7. pp. 1898-1900. July 1998. N. Cremades, K. Takahashi, M. Sousa, R. Bernabeu.

• Influence of gonadotrophin-releasing hormone agonist total dose in the ovarian stimulation in the long down-regulation protocol for in-vitro-fertilization
  Date: 01 November 1997

  Human Reproduction. Vol 12. No 11. Pp. 2366-2369. November 1997. C. Álvarez, N. Cremades, N. Blasco and R. Bernabeu.

• In Vitro matured metaphase I oocytes have a lower fertilization rate
  Date: 01 August 1996

  Human Reprod., 11. Abstract Book. P 090. 1996, Bonada M., Cremades N., Alvarez C, Bemabeu R., J. Ll. Aparicio. and Bernabeu S.

• Deletion of chromosome 13: 46, XY del (13) (q14->qter) after in vitro fertilization and tubal embryo transfer
  Date: 01 July 1996

  Journal of Assisted Reproduction and Genetics, Vol. 13, No 6. July 1996. M. Bonada, N. Cremades, F. Galán, R. Bernabeu.

• Sex selection may be inadvertently performed in in-vitro fertilization-embryo transfer programmes
  Date: 01 November 1995

  Human Reproduction. Vol. 10, No 11. pp. 2992-2998. November 1995. JJ. Tarín, A. Baviera, M. Bonada, A. Cano and R. Bernabeu.